With nginx it is quite easy to configure multiple domains or subdomains to be served from single server. Refer following configuration for the same.
server {
server_name first.pandurangpatil.com;
root /var/www/first;
}
server {
server_name second.pandurangpatil.com;
root /var/www/second;
}
server {
server_name someother.com;
root /var/www/other;
}